What is Gastrointestinal/Mesenteric Ischemia?

Gastrointestinal ischemia occurs when the blood supply to the gastrointestinal tract is decreased or cut off. The gastrointestinal tract includes the esophagus, stomach, small intestines, colon (large intestines), and rectum. Decreased blood flow limits the amount of oxygen available to these organs, which can lead to cell death and permanent organ damage. Colonic ischemia is the most common type of gastrointestinal ischemia.

The blood supply to the gastrointestinal tract comes from three branches of the aorta: the celiac artery, the superior mesenteric artery, and the inferior mesenteric artery. Because there is overlap between the areas that these arteries supply, the arteries can try to compensate for blockages in other areas. However, uncompensated areas will suffer more damage from decreased blood flow.

What are the Risk Factors of Mesenteric Ischemia?

Blood loss, decreased blood flow, narrowing of arteries, or complete blockage of arteries can cause ischemia. Artery narrowing or blockage can result from:

• Blood clots
• Atherosclerosis (hardened arteries caused by fatty deposits called plaques)
• Cardiovascular disease
• Aneurysms
• Tumors
• Hernias
• Conditions affecting blood cells or blood vessels, such as hypercoagulable conditions (increased clotting), sickle cell anemia, vasculitis, or lupus
• Certain medications, such as birth control pills, estrogen, and migraine medications
• Drugs, such as cocaine and methamphetamine

What are the Symptoms of Mesenteric Ischemia?

Symptoms will vary between acute (sudden onset) and chronic gastrointestinal ischemia. People with chronic gastrointestinal ischemia may suffer acute intestinal ischemia attacks, which are life-threatening.

Acute Gastrointestinal Ischemia

• Sudden abdominal pain
• Nausea
• Vomiting
• Fever
• Bloody stool
• Depending on the time after the ischemic attack began, there will be frequent bowel movements, no bowel movements, then massive fluid loss into the abdomen leading to shock.

Chronic Gastrointestinal Ischemia

• Abdominal pain or cramps that get worse over time
• Nausea
• Vomiting
• Malnutrition
• Weight loss
• Bloody diarrhea

How is Mesenteric Ischemia Diagnosed?

In addition to the medical history and symptoms, your vascular and interventional physician may perform:

• Abdominal ultrasound
• CT scan
• MRI
• Angiography (X-ray, CT, or MRI with contrast agent to visualize blood vessels)
• Endoscopy (using a camera to look inside the gastrointestinal tract)
• Blood tests

How is Mesenteric Ischemia Treated?

Treatments can vary depending on what is limiting blood flow. If calcified plaques have built up on the arterial walls and are obstructing flow, angioplasty may be performed. Angioplasty is performed by making a small incision in the groin and advancing a series of tubes and wires to the area of concern under x-ray guidance. The narrowed artery can then be widened with a balloon, a stent may also be placed.

If the flow is being blocked because a clot has become lodged in an artery the approach is slightly different. Accessing the area of concern is achieved with a series of wires and tubes under x-ray guidance as described above. Once the area of concern is reached a special catheter can be placed in the clot and clot-busting medication can be delivered to help break up the clot.