AUTHORS: Goddard JK, Nussbaum ES, Madison M, Lassig J, Torok C, Giannakidis D, Hanson S, McDonald W, Kallmes KM, Nussbaum LA.

Although cardiac myxomas have been known to cause acute ischemic stroke and other cerebrovascular complications, intracranial embolization of metastatic tumor fragments is rare. This is likely because venous emboli generally cause pulmonary embolism. Pulmonary vein metastases and patent foramen ovales have previously shown to propagate intracranial embolic carcinomas, but these events are very uncommon, and are not well characterized. We report a rare case of large-cell, high-grade neuroendocrine lung cancer embolus occluding the basilar artery, which likely detached into the bloodstream from the lung after intruding into a pulmonary vein. The embolus was treated with endovascular aspiration, and achieved modified Thrombolysis In Cerebral Infarction 2c revascularization. After initial neurological recovery, the patient suffered respiratory arrest and support was withdrawn 48 h later. We discuss the tumor characteristics and implications for treatment of acute ischemic stroke in patients with cancer diagnoses.

Interv Neuroradiol. 2019 Aug;25(4):403-406. doi: 10.1177/1591019918817224. Epub 2019 Feb 20. PMID: 30786802; PMCID: PMC6607611.